Endocrine Abstracts

Objective: The treatment with proton pump inhibitors (PPI; omeprazole, pantoprazole, lansoprazole) used for gastritis, gastric ulcer, etc. could lead to L-thyroxine (L-T4) malabsorption issues, that is induced by the increased gastric pH. Many factors like age, way of assumption (during breakfast or with food), other drugs interferences, drug-kinetics, adherence to therapy, could impair the L-T4 absorption.Methods: The study involved 27 hypothyroid patie...

Objective: Tablet levothyroxine (L-T4) is the common used therapy for hypothyroidism. In order to assess a good compliance to the therapy, treated patients are monitored with the execution of annual thyroid hormonal test. The stability of TSH levels in hypothyroid patients (with no malabsorption issues), treated with liquid L-T4, compared to that of the patients treated with tablet L-T4, remained a poorly understood topic. This study has the purpose to deepen this issue.<p...

Objective: An enhancement of the response rate has been recently showed in patients with Graves’ ophthalmopathy (GO) treated with corticosteroids and mycophenolic acid. In GO, retro-orbital cells showed a cytokine-induced secretion of Th1 and Th2 chemokines. Since no data are present in literature about the effect of corticosteroids and mycophenolic acid on the chemokines secretion in GO orbital cells, we aim to deepen out this topic.Methods: We est...

The risk of thyroid dysfunction induced by Interferon (IFN)-β1b therapy, in particular in patients having preexisting thyroid autoimmune disorders (AITD), is well known. We report a case of a 60-year-old female, with a 15-year history of euthyroid autoimmune thyroiditis and a 3-year history of Multiple Sclerosis (MS), in care for the evaluation of hyperthyroidism. The patient started a specific immunomodulant IFN-β1a therapy (30 μg/week) twenty months before the...

Autoimmune thyroid diseases (AITD) are organ specific autoimmune disorders with a T-cell-mediated immune attack directed against the thyroid. Hashimoto’s thyroiditis and Graves’ disease are the two principal AITD clinical presentations, which are characterized by hypothyroidism and thyrotoxicosis, respectively. We review the available data in literature about personalized medicine in patients with autoimmune thyroiditis (AT) and hypothyroidism. The synthetic Levothyr...

Anaplastic thyroid cancer (ATC) is one of the most lethal endocrine malignancy, with a mean survival of about 6 months. Until now, the most effective therapy for ATC comprises a multimodal treatment protocol, including surgery, chemotherapy (doxorubicin and cisplatin), and hyperfractionated accelerated external beam radiotherapy, with a median patient survival of 10 months. A possible increase in the effectiveness of the treatment could be achieved testing the sensitivity of &...

Introduction: CLM29, a pyrazolo[3,4-d]pyrimidine compound, inhibits several targets (including the RET tyrosine kinase, epidermal growth factor receptor, vascular endothelial growth factor receptor and has an anti-angiogenic effect). Recently it has been shown to inhibit proliferation and migration in primary papillary dedifferentiated thyroid cancer cells. The aim of this study is to evaluate the anti-tumor activity of CLM29 in medullary thyroid cancer (MTC).<p c...

Hypothyroidism is usually treated with levothyroxine (L-T4), that is present in different formulation. We aim to assess if hypothyroid patients have a better control of thyroid-stimulating hormone (TSH) levels by following a L-T4 therapy in a liquid formulation, with respect to the tablet formulation. We enrolled seven hundred hypothyroid patients treated with liquid L-T4, and three hundred and fifty hypothyroid subjects receiving tablet L-T4 (both groups were matched by age a...

Tablet levothyroxine (L-T4) is the common treatment for hypothyroidism. We aim to investigate the efficacy of L-T4 in liquid formulation in patients recently subjected to total thyroidectomy (without malabsorption or drug interference), with respect to L-T4 tablets. Eighty patients were treated with L-T4 in tablets, whereas one hundred and sixty received liquid L-T4 at the same dosage (1.5 mg/kg/day). All patients started the therapy the day after thyroidectomy, and the drugs ...

Anaplastic thyroid cancer (ATC) is usually treated with surgery, external hyperfractionated radiation therapy, and chemotherapy. However, because of the aggressiveness of this type of cancer, these treatments allow about 6-10 months of median survival. Therefore, it is challenging to predict the ATC patient clinical therapy responsiveness. Pazopanib is a multitarget tyrosine kinase inhibitor of VEGF receptors, PDGF, and c-Kit, and its effect in primary human ATC cells (pATC) h...